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Avoids forearm twisting for comfort and good health*. The patented shape supports your hand in an upright neutral posture that generally avoids forearm twisting. including medical doctors. ergonomists and physical therapists. said the Evoluent VerticalMouse provides superior comfort and even relieved their wrist pain. Comfortable and easy to use. The shape is thoughtfully sculpted for uncompromised comfort and easy-to-reach programmable buttons. No finger contortions are needed to operate the buttons. The thumb rest has been reshaped to provide even more comfort over earlier versions. A new bottom thumb button provides greatly extended functionality when used with the included driver. Extended lip prevents rubbing. An extra wide lip along the bottom edge prevents the last finger from rubbing the desk. Pointer speed controls on the side allow convenient adjustment without even releasing your grip from the mouse. Top mounted LEDs show through the chrome thumb rest to indicate selected pointer speed including extra low (XL). The logo is pure eye candy. The illumination turns off when the system is in sleep mode to conserve notebook battery power. Powerful and intuitive driver. Evoluent Mouse Manager for Windows provides extensive but easy to use functionality for 6 buttons through a simple and intuitive interface. Windows 7 Professional x64. Windows Vista Home Basic x64. Windows Vista Home Premium. Windows Vista Home Premium x64. Windows Vista Ultimate x64. Windows XP Professional x64.